Preparation containing diol

ABSTRACT

Disclosed is a cosmetic or dermatological formulation comprising a) at least one polyol in a concentration of from 0.1 to 20% by weight, based on the total weight of the formulation, and b) at least one diol selected from 2-methyl-1,3-propanediol, pentanediol, and hexanediol, in a concentration of from 0.1 to 25% by weight, based on the total weight of the formulation.

CROSS-REFERENCE TO RELATED APPLICATIONS

This is a continuation of U.S. Continuation application Ser. No.11/467,404, filed Aug. 25, 2006, which is a continuation of U.S.Continuation application Ser. No. 10/915,143, filed Aug. 9, 2004, whichis a continuation application of PCT/EP2003/001204, filed Feb. 7, 2003;all of these applications are incorporated by reference herein in theirentireties.

FIELD OF THE INVENTION

The present invention relates to cosmetic or dermatological formulationscomprising one or more polyols in a concentration of 0.1 to 20% byweight, one or more diols from the group consisting of2-methyl-1,3-propanediol, pentanediol, hexanediol in a concentration of0.1 to 25% by weight, in each case based on the total weight of theformulation, and the use thereof.

BACKGROUND OF THE INVENTION

The skin is the largest organ of humans. Its many functions (for examplefor regulation of heat and as a sense organ) include the barrierfunction, which prevents the skin (and therefore in the end the entireorganism) from drying out, certainly the most important. At the sametime, the skin acts as a protective device against penetration anduptake of substances from the outside. This barrier function is effectedthrough the epidermis, which as the outermost layer forms the actualprotective covering against the environment. With about one tenth of thetotal thickness, at the same time it is the thinnest layer of the skin.

The task of cosmetic skin care is to strengthen or re-establish thenatural function of the skin as a barrier against environmentalinfluences (for example dirt, chemicals, microorganisms) and against theloss of endogenous substances (for example water, natural fats,electrolytes).

The aim of skin care is furthermore to compensate for the loss of fatsby the skin caused by daily washing. This is important precisely if thenatural capacity for regeneration is not sufficient.

A central task of skin care is moisturizing of the skin. The moisturecontent of the skin has an important influence on its appearance and itsstate of health: the higher the water loss, the rougher and more friablethe skin becomes. Its elasticity and plasticity decrease, and itsintactness is no longer guaranteed. To moisturize the skin, moisturizingsubstances (moisturizers) which assist the water-binding capacity of thehorny layer are added to cosmetic and dermatological formulations.Conventional skin moisturizers, which are employed in almost allcosmetic and dermatological formulations, include the polyols, such asglycerol and sorbitol. In addition, other compounds are also employed,such as ethoxylated polyols and hydrolyzed proteins. Components of thenatural moisturizing factor of the skin (NMF), for example urea andcertain amino acids, are moreover used.

A great disadvantage of the prior art is the adverse sensory propertiesof cosmetic or dermatological formulations which comprisepolyol-containing moisturizing agents. As a rule, these feel tacky andgreasy on the skin and make the corresponding products unattractive tothe consumer. To suppress these negative properties, expensive siliconeoils and lipids, which increase the preparation costs of thecosmetic/dermatological compositions, must be added the formulations.

SUMMARY OF THE INVENTION

It was therefore the object of the present invention to eliminate thisdisadvantage of the prior art and to develop inexpensive cosmetic ordermatological formulations with significantly improved sensoryproperties. In particular, the formulations should not feel tacky. Thecontent of silicone oils and other lipids which reduce the tackinessshould be reduced.

Cosmetic and dermatological formulations are employed and consumed byconsumers worldwide in the most diverse climate zones. Since thedevelopment of cosmetics or dermatological agents is quite involved andexpensive, attempts are increasingly being made to develop recipes whichcan be employed globally under the most diverse climate conditions.However, the heat stability of these highly complex metastable mixturesis relatively limited. At low temperatures of below 5° C. theirviscosity increases so severely that the formulations can scarcely stillbe used or processed. The products also tend towards separating out ofwater and phase separation at low temperatures and with relatively widevariations in temperature, such as may occur, for example, duringtransportation.

It was therefore a further object of the present invention to developheat-stable cosmetic and dermatological formulations which, because oftheir low viscosity, can also still be used and processed at lowtemperatures. Surprisingly, these objects are achieved by cosmetic ordermatological formulations comprising

a) one or more polyols in a concentration of 0.1 to 20% by weight,

b) one or more diols from the group consisting of2-methyl-1,3-propanediol,

pentanediol, hexanediol in a concentration of 0.1 to 25% by weight, ineach case based on the total weight of the formulation.

The formulations according to the invention are distinguished by a highheat stability and low viscosity at low temperatures. Furthermore, theyhave excellent sensory properties, such as a low feeling of tackiness onthe skin.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

It is advantageous according to the invention to employ the polyols in aconcentration of 0.1 to 20% by weight, and in particular 1 to 15% byweight, based on the total weight of the formulation.

The polyols which are particularly preferred according to the inventionare glycerol, propylene glycol and butylene glycol.

It is furthermore advantageous according to the invention to employ thediols in a concentration of 1 to 15% by weight, and in particular 3 to8% by weight, based on the total weight of the formulation.

In this context, it is advantageous according to the invention if theratio of polyols to diols in the cosmetic or dermatological formulationsaccording to the invention is from 5:1 to 1:5, in particular 3:1 to 1:3,and very particularly preferably 2:1 to 1:1.

In this context, 2-methyl-1,3-propanediol is employed as a diol which isparticularly preferred according to the invention.2-Methyl-1,3-propanediol [INCI: Methyl Propanediol, for example MPDiol(Lyondell)] is an odorless moisturizing agent having the followingstructure:

The formulations in the context of the present invention can preferablyadditionally comprise, in addition to one or more oily phases, one ormore aqueous phases and can be, for example, in the form of W/O, O/W,W/O/W or O/W/O emulsions. Such formulations can preferably also be amicroemulsion, a solids emulsion (i.e. an emulsion which is stabilizedby solids, for example a Pickering emulsion), a sprayable emulsion or ahydrodispersion. Advantageous embodiments of the formulations accordingto the invention are, for example, ointments, creams and lotions. Theformulations in the context of the present invention can furthermorealso be anhydrous systems (powders, oils or wax sticks) or oil-freesystems (aqueous, aqueous/alcoholic or only alcoholic solutions). Theparticular corresponding emulsifiers can be employed for this purpose.

The cosmetic or dermatological formulations according to the inventioncan comprise cosmetic auxiliaries such as are conventionally used insuch formulations, for example emulsifiers, preservatives, preservationaids, bactericides, UV light protection filters, perfumes, agents whichbleach the skin, self-tanning agents, repellants, substances forpreventing foaming, dyestuffs, pigments which have a coloring action oract as UV light protection filters, thickeners, further moisturizingand/or moisture-retaining substances, fillers which improve thesensation on the skin, fats, oils, waxes or other conventionalconstituents of a cosmetic or dermatological formulation, such asalcohols, polymers, foam stabilizers, electrolytes, organic solvents orsilicone derivatives.

The aqueous phase of the formulations according to the invention canadvantageously comprise conventional cosmetic auxiliaries, such as, forexample, alcohols, in particular those of low C number, preferablyethanol or isopropanol, further diols or polyols of low C number andethers thereof, preferably ethylene glycol, ethylene glycol monoethyl ormonobutyl ether, propylene glycol monomethyl, monoethyl or monobutylether, diethylene glycol monomethyl or monoethyl ether and analogousproducts, polymers, foam stabilizers, electrolytes, dihydroxyacetoneand, in particular, one or more thickeners, which can advantageously bechosen from the group consisting of silicon dioxide, aluminum silicates,polysaccharides or derivatives thereof, for example hyaluronic acid,xanthan gum, hydroxypropylmethylcellulose, particularly advantageouslyfrom the group consisting of polyacrylates, preferably a polyacrylatefrom the group consisting of the so-called Carbopols, for exampleCarbopols of the types 980, 981, 1382, 2984, 5984, in each caseindividually or in combination.

Copolymers of C₁₀₋₃₀-alkyl acrylates and one or more monomers of acrylicacid, methacrylic acid or esters thereof are furthermore advantageous.

Compounds which bear the INCI name “Acrylates/C₁₀₋₃₀ Alkyl AcrylateCrosspolymer” are advantageous. Those obtainable under the trade namesPemulen TR1 and Pemulen TR2 from B. F. Goodrich Company are advantageousin particular.

Compounds which bear the INCI name AmmoniumAcryloyldimethyltaurate/Vinylpyrrolidone Copolymer are advantageous.

Advantageously, according to the invention, the ammoniumacryloyldimethyltaurate/Vinylpyrrolidone copolymer(s) advantageouslyhave the empirical formula [C₇H₁₆N₂SO₄]_(n), [C₆H₉NO]_(m), correspondingto a statistical structure as follows

Preferred species in the context of the present invention are filed inthe Chemical Abstracts under Registry Numbers 58374-69-9, 13162-05-5 and88-12-0 and are obtainable under the trade name Aristoflex® AVC fromClariant GmbH.

Copolymers/crosspolymers comprising Acryloyldimethyl Taurate, such as,for example, Simugel® EG or Simugel® EG from Seppic S.A. are furthermoreadvantageous.

Further thickeners which are advantageously to be used according to theinvention are also polyurethanes which are soluble or dispersible inwater. Polyurethane-1 or polyurethane-4, for example, are advantageousin the context of the present invention.

Particularly advantageous polyurethanes in the context of the presentinvention are the types available under the trade name Avalure™ UR fromB. F. Goodrich Company, such as, for example, Avalure™ UR 445, Avalure™UR 450 and the like. The polyurethane obtainable under the trade nameLuviset Pur from BASF is furthermore advantageous in the context of thepresent invention.

The cosmetic or dermatological formulations according to the inventioncan furthermore advantageously, although not necessarily, comprisefillers, which for example further improve the sensory and cosmeticproperties of the formulations and, for example, cause or intensify avelvety or silky sensation on the skin. Advantageous fillers in thecontext of the present invention are starch and starch derivatives (suchas for example tapioca starch, distarch phosphate, aluminum or sodiumstarch octenyl succinate and the like), pigments which have neither achiefly UV filter nor a coloring action (such as for example boronnitride etc.) and Aerosils® (CAS no. 7631-86-9).

The oily phase of the cosmetic or dermatological formulations accordingto the invention is advantageously chosen from the group consisting ofpolar oils, for example from the group consisting of lecithins and fattyacid triglycerides, namely the triglycerol esters of saturated orunsaturated, branched or unbranched alkanecarboxylic acids of a chainlength of 8 to 24, in particular 12 to 18 C atoms. The fatty acidtriglycerides can advantageously be chosen, for example, from the groupconsisting of synthetic, semi-synthetic and naturally occurring oils,such as for example coco-glyceride, olive oil, sunflower oil, soya oil,groundnut oil, rapeseed oil, almond oil, palm oil, coconut oil, castoroil, wheat germ oil, grape seed oil, thistle oil, evening primrose oil,macadamia nut oil and more of the like.

Naturally occurring waxes of animal and plant origin for example arefurthermore advantageous according to the invention, such as, forexample, beeswax and other insect waxes and berry wax, shea butter andlanolin (wool wax).

Further advantageous polar oil components can furthermore be chosen inthe context of the present invention from the group consisting of estersof saturated or unsaturated, branched or unbranched alkanecarboxylicacids of a chain length of 3 to 30 C atoms and saturated or unsaturated,branched or unbranched alcohols of a chain length of 3 to 30 C atoms andfrom the group consisting of esters of aromatic carboxylic acids andsaturated or unsaturated, branched or unbranched alcohols of a chainlength of 3 to 30 C atoms. Such ester oils can then advantageously bechosen from the group consisting of octyl palmitate, octyl cocoate,octyl isostearate, octyl dodeceylmyristate, octyldodecanol, cetearylisononanoate, isopropyl myristate, isopropyl palmitate, isopropylstearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyloleate, isooctyl stearate, isononyl stearate, isononyl isononanoate,2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate,2-octyldodecyl palmitate, stearyl heptanoate, oleyl oleate, oleylerucate, erucyl oleate, erucyl erucate, tridecyl stearate, tridecyltrimellitate, and synthetic, semi-synthetic and naturally occurringmixtures of such esters, such as for example jojoba oil.

The oily phase can furthermore advantageously be chosen from the groupconsisting of dialkyl ethers and dialkyl carbonates, and advantageouscompounds are for example dicaprylyl ether (Cetiol OE) and dicaprylylcarbonate, for example that obtainable under the trade name Cetiol CCfrom Cognis.

It is furthermore preferable to have the oil component(s) from the groupconsisting of isoeicosane, neopentylglycol diheptanoate, propyleneglycol dicaprylate/dicaprate, caprylic/capric/diglyceryl succinate,butylene glycol dicaprylate/dicaprate, coco-glycerides (for exampleMyritol® 331 from Henkel), C₁₂₋₁₃-alkyl lactate, di-C₁₂₋₁₃-alkyltartrate, triisostearin, di pentaerythrityl hexacaprylate/hexacaprate,propylene glycol monoisostearate, tricaprylin, dimethyl isosorbide. Itis particularly advantageous if the oily phase of the formulationsaccording to the invention has a content of C₁₂₋₁₅-alkyl benzoate, orconsists entirely of this.

Advantageous oil components are furthermore for example butyloctylsalicylate (for example that obtainable under the trade name HallbriteBHB from CP Hall), hexadecyl benzoate and butyloctyl benzoate andmixtures thereof (Hallstar AB) and diethylhexyl naphthalate (HallbriteTQ from CP Hall or Corapan®TQ from Haarmann & Reimer).

Any desired blends of such oil and wax components are alsoadvantageously to be employed in the context of the present invention.

The oily phase can furthermore likewise advantageously also comprisenon-polar oils, for example those which are chosen from the groupconsisting of branched and unbranched hydrocarbons and hydrocarbonwaxes, in particular mineral oil, Vaseline (petrolatum), paraffin oil,squalane and squalene, polyolefins, hydrogenated polyisobutenes andisohexadecane. Among the polyolefins, polydecenes are the preferredsubstances.

The oily phase can furthermore advantageously have a content of cyclicor linear silicone oils or consist entirely of such oils, although it ispreferable to use an additional content of other oily phase componentsin addition to the silicone oil or the silicone oils.

Silicone oils are high molecular weight synthetic polymeric compounds inwhich silicon atoms are linked in a chain- or net-like manner via oxygenatoms and the remaining valencies of the silicon are satisfied byhydrocarbon radicals (usually methyl groups, less frequently ethyl,propyl, phenyl groups and the like). The silicone oils aresystematically called polyorganosiloxanes. The methyl-substitutedpolyorganosiloxanes, which represent the most important compounds ofthis group in terms of amount, are distinguished by the followingstructural formula

are also called polydimethylsiloxane or dimethicone (INCI). There aredimethicones in various chain lengths and with various molecularweights.

Particularly advantageous polyorganosiloxanes in the context of thepresent invention are, for example, dimethylpolysiloxanes[poly(dimethylsiloxane)], which are obtainable, for example, under thetrade names Abil 10 to 10 000 from Th. Goldschmidt.Phenylmethylpolysiloxanes (INCI: Phenyl Dimethicone, PhenylTrimethicone) cyclic silicones (octamethylcyclotetrasiloxane ordecamethylcyclopentasiloxane), which according to the INCI are alsocalled Cyclomethicone, amino-modified silicones (INCI: Amodimethicone)and silicone waxes, for example polysiloxane/polyalkylene copolymers(INCI: Stearyl Dimethicone and Cetyl Dimethicone) anddialkoxydimethylpolysiloxanes (Stearoxy Dimethicone and Behenoxy StearylDimethicone), which are obtainable as various Abil wax types from Th.Goldschmidt, are furthermore advantageous. However, other silicone oilsare also advantageously to be used in the context of the presentinvention, for example cetyldimethicone, hexamethylcyclotrisiloxane,polydimethylsiloxane, poly(methylphenylsiloxane).

Advantageous preservatives in the context of the present invention are,for example, agents which split off formaldehyde (such as for exampleDMDM hydantoin, which is obtainable, for example, under the trade nameGlydant™ from Lonza), iodopropyl butyl carbamates (for example thoseobtainable under the trade names Glydant-2000, Glycacil-L, Glycacil-Sfrom Lonza or Dekaben LMB from Jan Dekker), parabens (i.e.p-hydroxybenzoic acid alkyl esters, such as methyl, ethyl, propyl orbutyl paraben), phenoxyethanol, ethanol, benzoic acid and more of thelike. The preservation system furthermore advantageously alsoconventionally comprises, according to the invention, preservation aids,such as, for example, ethyl hexyloxyglycerol, glycine soya etc.

Particularly advantageous formulations are furthermore obtained ifantioxidants are employed as additives or active compounds. According tothe invention, the formulations advantageously comprise one or moreantioxidants. All the antioxidants which are suitable or usual forcosmetic or dermatological uses can be used as antioxidants which arefavorable but nevertheless optionally to be used.

Water-soluble antioxidants, such as, for example, vitamins, for exampleascorbic acid and derivatives thereof, can be particularlyadvantageously employed in the context of the present invention.

Preferred antioxidants are furthermore vitamin E and derivatives thereofand vitamin A and derivatives thereof.

The amount of antioxidants (one or more compounds) in the formulationsis preferably 0.001 to 30 wt. %, particularly preferably 0.05 to 20 wt.%, in particular 0.1 to 10 wt. %, based on the total weight of theformulation.

If vitamin E and/or derivatives thereof are the antioxidant(s), it isadvantageous to choose the particular concentration thereof from therange from 0.001 to 10 wt. %, based on the total weight of theformulation.

If vitamin A or vitamin A derivatives or carotenes or derivativesthereof are the antioxidant(s), it is advantageous to choose theparticular concentrations thereof from the range from 0.001 to 10 wt. %,based on the total weight of the formulation.

It is particularly advantageous if the cosmetic or dermatologicalformulations according to the present invention comprise cosmetic ordermatological active compounds, preferred active compounds beingantioxidants which can protect the skin from oxidative stress.

Further advantageous active compounds in the context of the presentinvention are naturally occurring active compounds and derivativesthereof, such as for example alpha-liponic acid, phytoene, D-biotin,coenzyme Q10, alpha-glucosylrutin, carnitine, carnosine, naturallyoccurring or synthetic isoflavonoids, creatine, taurine and/orβ-alanine.

Recipes according to the invention which for example comprise knownantiwrinkling active compounds, such as flavone glycosides (inparticular α-glycosylrutin), coenzyme Q10, vitamin E and derivatives andthe like, are particularly advantageously suitable for the prophylaxisand treatment of cosmetic or dermatological skin changes, such as occurfor example during ageing of the skin (such as, for example, dryness,roughness and development of dryness wrinkles, itching, reducedre-oiling (for example after washing), visible dilations of vessels(telangiectases, cuperosis), flaccidity and the development of folds andwrinkles, local hyper-, hypo- and dyspigmentations (for example senilekeratosis), increased susceptibility to mechanical stress (for examplechapping) and the like). They are moreover advantageously suitableagainst the development of dry or rough skin. Cosmetic or dermatologicalformulations in the context of the present invention can advantageouslycomprise at least one UV-A, UV-B and/or broad-band filter substance. Theformulations may, although not necessarily, optionally also comprisefurther organic or inorganic pigments as UV filter substances, which canbe present in the aqueous and/or the oily phase.

UV filter substances which are liquid at room temperature and areparticularly advantageous in the context of the present invention arehomomenthyl salicylate (INCI: Homosalate), 2-ethylhexyl2-cyano-3,3-diphenylacrylate (INCI: Octocrylene), 2-ethylhexyl2-hydroxybenzoate (2-ethylhexyl salicylate, octyl salicylate, INCI:Octyl Salicylate) and esters of cinnamic acid, preferably4-methoxycinnamic acid (2-ethylhexyl) ester (2-ethylhexyl4-methoxycinnamate, INCI: Octyl Methoxycinnamate) and 4-methoxycinnamicacid isopentyl ester (isopentyl 4-methoxycinnamate, INCI: Isoamylp-Methoxycinnamate).

Advantageous UV-A filter substances in the context of the presentinvention are dibenzoylmethane derivatives, in particular4-(tert-butyl)-4′-methoxydibenzoylmethane (CAS no. 70356-09-1), which issold by Givaudan under the trademark Parsol® 1789 and by Merck under thetrade name Eusolex® 9020.

Advantageous further UV filter substances in the context of the presentinvention are sulphonated, water-soluble UV filters, such as forexample:

-   -   phenylene-1,4-bis-(2-benzimidazyl)-3,3′-5,5′-tetrasulphonic acid        and its salts, in particular the corresponding sodium, potassium        or triethanolammonium salts, in particular        phenylene-1,4-bis-(2-benzimidazyl)-3,3′-5,5′-tetrasulphonic acid        bis-sodium salt with the INCI name Bisimidazylate (CAS no.:        180898-37-7), which is obtainable, for example, under the trade        name Neo Heliopan AP from Haarmann & Reimer;    -   salts of 2-phenylbenzimidazole-5-sulphonic acid, such as its        sodium, potassium or its triethanolammonium salt, and the        sulphonic acid itself with the INCI name Phenylbenzimidazole        Sulphonic Acid (CAS no. 27503-81-7), which is obtainable, for        example, under the trade name Eusolex 232 from Merck or under        Neo Heliopan Hydro from Haarmann & Reimer;    -   1,4-di(2-oxo-10-sulpho-3-bornylidenemethyl)-benzene (also:        3,3′-(1,4-phenylenedimethyleneybis-(7,7-dimethyl-2-oxo-bicyclo-[2.2.1]hept-1-ylmethanesulphonic        acid) and salts thereof (especially the corresponding        10-sulphato compounds, in particular the corresponding sodium,        potassium or triethanolammonium salt), which is also called        benzene-1,4-di(2-oxo-3-bornylidenemethyl-10-sulphonic acid).        Benzene-1,4-di(2-oxo-3-bornylidenemethyl-10-sulphonic acid has        the INCI name Terephthalidene Dicamphor Sulphonic Acid (CAS no.:        90457-82-2) and is obtainable, for example, under the trade name        Mexoryl SX from Chimex;    -   sulphonic acid derivatives of 3-benzylidenecamphor, such as for        example 4-(2-oxo-3-bornylidenemethyl)benzenesulphonic acid,        2-methyl-5-(2-oxo-3-bornylidenemethyl)sulphonic acid and salts        thereof.

Advantageous UV filter substances in the context of the presentinvention are furthermore so-called broad-band filters, i.e. filtersubstances which absorb both UV-A and UV-B radiation.

Advantageous broad-band filters or UV-B filter substances are, forexample, triazine derivatives, such as for example

-   -   2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine        (INCI: Aniso Triazine), which is obtainable under the trade name        Tinosorb® S from CIBA-Chemikalien GmbH;    -   diethylhexylbutylamidotriazone (INCI:        Diethylhexylbutamidotriazone), which is obtainable under the        trade name UVASORB HEB from Sigma 3V;    -   4,4′,4″-(1,3,5-triazine-2,4,6-triyltriimino)-tris-benzoic acid        tris(2-ethylhexyl ester), also:        2,4,6-tris-[anilino-(p-carbo-2′-ethyl-1′-hexyloxy)]-1,3,5-triazine        (INCI: ethylhexyl triazone), which is marketed by BASF        Aktiengesellschaft under the trade name UVINUL® T 150.

The further UV filter substances can be oil-soluble or water-soluble.

Advantageous oil-soluble UV-B and/or broad-band filter substances in thecontext of the present invention are for example:

-   -   3-benzylidenecamphor derivatives, preferably        3-(4-methylbenzylidene)camphor, 3-benzylidenecamphor;    -   4-aminobenzoic acid derivatives, preferably        4-(dimethylamino)-benzoic acid (2-ethylhexyl) ester,        4-(dimethylamino)benzoic acid amyl ester;    -   derivatives of benzophenone, preferably        2-hydroxy-4-methoxybenzophenone,        2-hydroxy-4-methoxy-4′-methylbenzophenone,        2,2′-dihydroxy-4-methoxybenzophenone    -   and UV filters bonded to polymers.    -   (3-(4-(2,2-bis        ethoxycarbonylvinyl)-phenoxy)propenyl)-methoxysilane/dimethylsiloxane—copolymer        which is obtainable, for example, under the trade name Parsol®        SLX from Hoffmann La Roche.

Further light protection filter substances which are advantageously tobe used according to the invention are ethylhexyl2-cyano-3,3-diphenylacrylate (octocrylene), which is obtainable fromBASF under the name Uvinul® N 539, and hydroxybenzophenones, such as2-(4′-(diethylamino)-2′-hydoxybenzoyl)-benzoic acid hexyl ester.

Particularly advantageous formulations in the context of the presentinvention which are distinguished by a high or very high UV-A and/orUV-B protection preferably furthermore comprise, in addition to thefilter substance(s) according to the invention, further UV-A and/orbroad-band filters, in particular dibenzoylmethane derivatives [forexample 4-(tert-butyl)-4′-methoxydibenzoylmethane],phenylene-1,4-bis-(2-benzimidazyl)-3,3′-5,5′-tetrasulphonic acid and/orits salts, 1,4-di(2-oxo-10-sulpho-3-bornylidenemethyl)-benzene and/orsalts thereof and/or2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine,in each case individually or in any desired combinations with oneanother.

The list of UV filters mentioned which can be employed in the context ofthe present invention is of course not intended to be limiting.

The formulations according to the invention advantageously comprise thesubstances which absorb UV radiation in the UV-A and/or UV-B range in atotal amount of for example 0.1 wt. % to 30 wt. %, preferably 0.5 to 20wt. %, in particular 1.0 to 15.0 wt. %, in each case based on the totalweight of the formulations, in order to provide cosmetic formulationswhich protect the hair or the skin from the entire range of ultravioletradiation.

Preferred further inorganic pigments are metal oxides or other metalcompounds which are sparingly soluble or insoluble in water, inparticular oxides of titanium (TiO₂), zinc (ZnO), iron (for exampleFe₂O₃), zirconium (ZrO₂), silicon (SiO₂), manganese (for example MnO),aluminum (Al₂O₃), cerium (for example Ce₂O₃), mixed oxides of thecorresponding metals and blends of such oxides as well as bariumsulphate (BaSO₄).

In the context of the present invention, the pigments can advantageouslyalso be used in the form of commercially obtainable oily or aqueouspredispersions. Dispersing auxiliaries and/or solubilization mediatorscan advantageously be added to these predispersions.

According to the invention, the pigments can advantageously be treatedon the surface (“coated”), whereby, for example, a hydrophilic,amphiphilic or hydrophobic character is to be formed or retained. Thissurface treatment can comprise providing the pigments with a thinhydrophilic or hydrophobic inorganic or organic layer by processes knownper se. The various surface coatings can also comprise water in thecontext of the present invention.

It may furthermore be of advantage, where appropriate, to incorporatefilm-forming agents into the formulations according to the invention,for example in order to improve the water-resistance of the formulationsor to increase the UV protection performance (UV-A and/or UV-Bboosting). Both water-soluble or dispersible and fat-solublefilm-forming agents, in each case individually or in combination withone another, are suitable.

Advantageous water-soluble or dispersible film-forming agents are forexample polyurethanes (for example the Avalure® types from Goodrich),Dimethicone Copolyol Polyacrylate (Silsoft Surface® from Witco OrganoSilicones Group), PVP/VA (VA=vinyl acetate) copolymer (Luviscol VA 64Powder from BASF) etc.

Advantageous fat-soluble film-forming agents are for example thefilm-forming agents from the group consisting of polymers based onpolyvinylpyrrolidone (PVP)

Copolymers of polyvinylpyrrolidone, for example PVP Hexadecene Copolymerand PVP Eicosene Copolymer, which are obtainable under the trade namesAntaron V216 and Antaron V220 from GAF Chemicals Cooperation, andTricontayl PVP and more of the like are particularly preferred.

According to their make-up, cosmetic or topical dermatologicalcompositions in the context of the present invention can be used, forexample, as skin protection cream, cleansing milk, make-up remover, dayor night cream etc. It may be possible and advantageous to use thecompositions according to the invention as a base for pharmaceuticalformulations. Generally, the invention relates to the use offormulations according to the invention as an ointment, cream, milk,lotion or spray for protecting the skin and/or skin appendages and/oragainst UV radiation.

The invention furthermore relates to the use of diols for improving thesensory properties, in particular for reducing the tacky sensation onthe skin, of polyol-containing cosmetic or dermatological formulations,the use of diols for reducing the viscosity of cosmetic ordermatological formulations at temperatures below 10° C. and the use ofdiols for increasing the stability of cosmetic or dermatologicalformulations

The invention also relates to the use of 2-methyl-1,3-propanediol as amoisturizing agent.

The following examples are intended to illustrate the present inventionwithout limiting it. Unless stated otherwise, all the amounts data,contents and percentage contents are based on the weight and the totalamount or on the total weight of the formulations.

W/O Emulsions

1 2 3 4 5 Triglycerol diisostearate 1.0 0.5  0.25 2.0 3.0 Diglycerol 1.01.5  1.75 3.0 2.0 dipolyhydroxystearate Paraffin oil 12.5  10.0  8.0 5.07.5 Vaseline 1.0 — 1.5 — — Hydrogenated 0.5 0.1 1.5 —  0.25 coconutglycerides Decyl oleate 0.5  0.75 1.0 2.0  0.25 Octyldodecanol 0.5 1.0 0.75 3.0  0.25 Aluminum stearate  0.04 — — 0.2  0.05 Dicaprylylcarbonate 0.1  0.05  0.15 0.5 1.0 Magnesium sulphate 0.5 0.6 0.5 0.7 1.0Glycerol — 5.0 — 15.0  5   Propylene glycol 5.0 — 10.0  — — Butyleneglycol — — — — 5.0 2-Methyl-1,3- 5.0 2.5 10.0  8.5 1.0 propanediolCitric acid 0.2 0.1 0.2 0.3 1.0 Perfume q.s. q.s. q.s. q.s. q.s. Ethanol2.0 — 5.0 — 10.0  Caprylic/capric 2.0 2.5 3.0 5.0 0.5 acid triglycerideMethyl paraben 0.4  0.15  0.05 0.3 0.4 Propyl paraben 0.3 0.4  0.25 0.15 — Iodopropynyl — —  0.05 — 0.1 butyl carbamate Water to 100 to 100to 100 to 100 to 100

W/O Emulsions

6 7 8 9 10 PEG-30 — 0.5 0.25 — 3.0 Dipolyhydroxystearate Lanolin Alcohol1.0 1.5 1.75 3.0 — Paraffin oil 12.5  10.0  8.0 5.0 17.5  Vaseline 8.06.0 5.0 2.0 2.5 2-Methyl-1,3- 5.0 2.5 15.0 7.5 10.0  propanediolHydrogenated 0.5  0.75 1.0 2.0  0.25 polyisobutene Octyldodecanol 0.51.0 0.75 3.0  0.25 Aluminum stearate 0.4 0.3 0.6 1.0  0.05 Dicaprylylcarbonate 0.1  0.05 0.15 0.5 1.0 Hydrogenated castor oil 0.5  0.75 1.02.5 5.0 Magnesium sulphate 0.5 0.6 0.5 0.7 1.0 Glycerol 3.0 5.0 — — 2.0Propylene glycol 5.0 — 10.0 — — Butylene glycol — — — 3.0 5.0 Citricacid 0.2 0.1 0.2 0.3 1.0 Perfume q.s. q.s. q.s. q.s. q.s. 1,3-Butyleneglycol 2.0 — 5.0 — — Caprylic/capric 2.0 2.5 3.0 5.0 0.5 acidtriglyceride Methyl paraben 0.4  0.15 0.05 0.3 0.4 Propyl paraben 0.30.4 0.25  0.15 — Water to 100 to 100 to 100 to 100 to 100

W/O Emulsions

11 12 13 14 15 Cetyl dimethicone 1.0 — — 3.0 5.0 copolyolCylomethicone + 10.0  12.5  25 — — PEG/PPG-18/18 DimethiconeCyclomethicone 12.5  15   8 25.0  17.5  Dimethicone 5.0 13.0  5.0 12.0 15.0  Hydrogenated 0.5  0.75 1.0 2.0  0.25 polyisobutene Octyldodecanol0.5 1.0 0.75 3.0  0.25 Panthenol 0.5 1.0 0.75  0.25 0.1 Sodium chloride2.0 0.6 2.5 0.7 1.0 Glycerol 3.0 — 2.0 3.0 15   Propylene glycol 5.0 5.05.0 — — Butylene glycol — — 4.0 — 2.0 2-Methyl-1,3- 15.0  2.5 10.0 8.51.0 propanediol Citric acid 0.2 0.1 0.2 0.3 1.0 Perfume q.s. q.s. q.s.q.s. q.s. Methyl paraben 0.4 0.1 0.05 0.3 0.4 Propyl paraben 0.3 0.40.25  0.15 — Cetyldimethicone 0.5 — 0.7 — — Iodopropynyl — — 0.05 — 0.1butyl carbamate Modified starch — 2.5 —  0.15 — Water to 100 to 100 to100 to 100 to 100

W/S Emulsions

16 17 18 19 20 Cetyl dimethicone 1.0 — — 3.0 5.0 copolyolCylomethicone + 10.0  12.5  25 — — PEG/PPG-18/18 DimethiconeCyclomethicone 12.5  15   28.0 25.0  17.5  Dimethicone 5.0 13.0  5.012.0  15.0  Hydrogenated 0.5  0.75 1.0 2.0  0.25 polyisobuteneOctyldodecanol 0.5 1.0 0.75 3.0  0.25 Panthenol 0.5 1.0 0.75  0.25 0.12-Methyl-1,3- 5.0 2.5 10.0 8.5 1.0 propanediol Glycerol 3.0 — 2.0 3.015   Propylene glycol 5.0 5.0 5.0 — — Butylene glycol — — 4.0 — 2.0Sodium chloride 2.0 0.6 2.5 0.7 1.0 Sorbitol 3.0 5.0 10.0 15.0  1.5Citric acid 0.2 0.1 0.2 0.3 1.0 Perfume q.s. q.s. q.s. q.s. q.s. Methylparaben 0.4 0.1 0.05 0.3 0.4 Propyl paraben 0.3 0.4 0.25  0.15 —Stearyldimethicone 0.5 — 0.7 — — Iodopropynyl — — 0.05 — 0.1 butylcarbamate Modified starch — 2.5 —  0.15 — Water to 100 to 100 to 100 to100 to 100

Oil-in-Water Emulsions

21 22 23 24 25 Glyceryl sterate 1.0 — — 3.0 5.0 PEG-40 stearate 10.0  —5 — — Triglycerol — 5.5 — — 2.5 methylglucose distearate Sorbitanstearate — 1.5 3 — — Cyclomethicone 1   2.5 5 7.5 3   Dimethicone 5.013.0  5.0 12.0 15.0  Behenyl alcohol 0.1 — 0.2 0.5 — Stearyl alcohol —1   — 1 — Cetylstearyl alcohol — — 0.1 1 — Hydrogenated 0.5  0.75 1.02.0  0.25 polyisobutene Octyldodecanol 0.5 1.0 0.75 3.0  0.252-Methyl-1,3- 5.0 2.5 10.0 8.5 1.0 propanediol Panthenol 0.5 1.0 0.750.25 0.1 Glycerol 3.0 — 2.0 3.0 15   Propylene glycol 5.0 5.0 5.0 — —Butylene glycol — — 4.0 — 2.0 Perfume q.s. q.s. q.s. q.s. q.s. Methylparaben 0.4 0.1 0.05 0.3 0.4 Propyl paraben 0.3 0.4 0.25 0.15 —Iodopropynyl — — 0.05 — 0.1 butyl carbamate Modified starch — 2.5 — 0.15— Water to 100 to 100 to 100 to 100 to 100

Oil-in-Water Emulsions

26 27 28 29 30 Polyethylene glycol 1 — 2.5 2 1.5 (21) stearyl etherPolyethylene glycol 1 — 1.5 3 1.5 (2) stearyl ether Cetearyl glucoside —8   — — — Cyclomethicone 2.5 3   12.5  2 8.0 Dimethicone 5.0 13.0  5.012.0 5.0 Behenyl alcohol 0.3 0.5 — 0.1 — Stearyl alcohol 0.3 — — 0.2 —Cetylstearyl alcohol 0.3 0.5 — —  0.25 Hydrogenated 0.5  0.75 1.0 2.0 0.25 polyisobutene Octyldodecanol 0.5 1.0  0.75 3.0  0.25 2-Methyl-1,3-15.0  2.5 10.0  8.5 25.0  propanediol Panthenol 0.5 1.0  0.75 0.25 0.1Glycerol 3.0 — 2.0 3.0 15   Propylene glycol 5.0 5.0 5.0 — — Butyleneglycol — — 4.0 — 2.0 Perfume q.s. q.s. q.s. q.s. q.s. Methyl paraben 0.40.1  0.05 0.3 0.4 Propyl paraben 0.3 0.4  0.25 0.15 — Iodopropynyl — — 0.05 — 0.1 butyl carbamate Modified starch — 2.5 — 0.15 — Water to 100to 100 to 100 to 100 to 100

What is claimed is:
 1. A cosmetic or dermatological formulation, whereinthe formulation comprises (a) one or more of glycerol, propylene glycol,and butylene glycol in a total concentration of from 0.1% to 20% byweight, based on a total weight of the formulation, (b)2-methyl-1,3-propanediol and, optionally, one or both of pentanediol andhexanediol in a total concentration of from 1% to 25% by weight, basedon the total weight of the formulation, 2-methyl-1,3-propanediol beingpresent in a concentration of from 1% to 15% by weight, and (c) at leastone substance selected from antioxidants, alpha-lipoic acid, phytoene,D-biotin, coenzyme Q10, α-glucosylrutin, carnitine, carnosine,isoflavonoids, creatine, taurine, and β-alanine, and wherein a ratio of(a) to (b) is from 5:1 to 1:1.
 2. The formulation of claim 1, whereinthe formulation is present as an ointment, a cream, a milk, a lotion ora spray.
 3. The formulation of claim 1, wherein glycerol, propyleneglycol, butylene glycol and 2-methyl-1,3-propanediol are present in atotal concentration of at least 7.5% by weight.
 4. The formulation ofclaim 1, wherein (a) comprises glycerol.
 5. The formulation of claim 1,wherein (b) comprises pentanediol.
 6. The formulation of claim 1,wherein (b) comprises hexanediol.
 7. The formulation of claim 1, wherein(c) comprises at least one substance selected from alpha-lipoic acid,phytoene, D-biotin, coenzyme Q10, α-glucosylrutin, carnitine, carnosine,isoflavonoids, creatine, taurine, and β-alanine.
 8. The formulation ofclaim 1, wherein (b) is present in a total concentration of from 3% to8% by weight.
 9. The formulation of claim 8, wherein (a) is present in atotal concentration of from 1% to 15% by weight.
 10. The formulation ofclaim 9, wherein the ratio of (a) to (b) is from 2:1 to 1:1.
 11. Theformulation of claim 1, wherein (a) comprises at least one of propyleneglycol and butylene glycol.
 12. A cosmetic or dermatologicalformulation, wherein the formulation is present as an ointment, a cream,a milk, a lotion or a spray and comprises (a) one or both of propyleneglycol and butylene glycol and, optionally, glycerol in a totalconcentration of from 0.1% to 20% by weight, based on a total weight ofthe formulation, and (b) 2-methyl-1,3-propanediol and, optionally, oneor both of pentanediol and hexanediol in a total concentration of from 1to 25% by weight, based on the total weight of the formulation,2-methyl-1,3-propanediol being present in a concentration of from 1% to15% by weight, and wherein a ratio of (a) to (b) is from 1:3 to 3:1. 13.The formulation of claim 12, wherein the formulation is present as anointment, a cream, a milk, a lotion or a spray.
 14. The formulation ofclaim 13, wherein glycerol, propylene glycol, butylene glycol and2-methyl-1,3-propanediol are present in a total concentration of atleast 7.5% by weight.
 15. The formulation of claim 13, wherein (b) ispresent in a total concentration of from 3% to 8% by weight.
 16. Theformulation of claim 12, wherein the ratio of (a) to (b) is from 2:1 to1:1.
 17. A cosmetic or dermatological formulation, wherein theformulation comprises (a) one or more of glycerol, propylene glycol, andbutylene glycol in a total concentration of from 0.1% to 20% by weight,based on a total weight of the formulation, and (b)2-methyl-1,3-propanediol and one or both of pentanediol and hexanediolin a total concentration of from 1% to 25% by weight, based on the totalweight of the formulation, 2-methyl-1,3-propanediol being present in aconcentration of from 1% to 15% by weight, and wherein a ratio of (a) to(b) is from 1:3 to 3:1.
 18. The formulation of claim 17, wherein theformulation is present as an ointment, a cream, a milk, a lotion or aspray.
 19. The formulation of claim 18, wherein (b) is present in atotal concentration of from 3% to 8% by weight.
 20. The formulation ofclaim 19, wherein the ratio of (a) to (b) is from 2:1 to 1:1.